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KMID : 0923620140140020073
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Immune Network
2014 Volume.14 No. 2 p.73 ~ p.80
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Advances in Systems Biology Approaches for Autoimmune Diseases
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Kim Ho-Youn
Kim Hae-Rim
Lee Sang-Heon
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Abstract
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Because autoimmune diseases (AIDs) result from a complex combination of genetic and epigenetic factors, as well as an altered immune response to endogenous or exogenous anti-gens, systems biology approaches have been widely applied. The use of multi-omics approaches, including blood tran-scriptomics, genomics, epigenetics, proteomics, and metab-olomics, not only allow for the discovery of a number of bio-markers but also will provide new directions for further trans-lational AIDs applications. Systems biology approaches rely on high-throughput techniques with data analysis platforms that leverage the assessment of genes, proteins, metabo-lites, and network analysis of complex biologic or pathways implicated in specific AID conditions. To facilitate the discov-ery of validated and qualified biomarkers, better-coordinated multi-omics approaches and standardized translational re-search, in combination with the skills of biologists, clinicians, engineers, and bioinformaticians, are required.
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KEYWORD
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Autoimmune diseases, Systems biology, Multi-omics, Biomarker, Translational research, Network analysis
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